Prenatal diethylstilbestrol exposure and mammographic density
نویسندگان
چکیده
منابع مشابه
Prenatal diethylstilbestrol exposure and risk of breast cancer.
It has been hypothesized that breast cancer risk is influenced by prenatal hormone levels. Diethylstilbestrol (DES), a synthetic estrogen, was widely used by pregnant women in the 1950s and 1960s. Women who took the drug have an increased risk of breast cancer, but whether risk is also increased in the daughters who were exposed in utero is less clear. We assessed the relation of prenatal DES e...
متن کاملLesions of testis and epididymis associated with prenatal diethylstilbestrol exposure.
Cryptorchidism and retention of Müllerian duct structures occur with high frequency among the male offspring of CD-1 mice treated with 100 micrograms diethylstilbestrol/kg body weight on days 9 through 16 of pregnancy. Hyperplasia of the rete testis and Müllerian duct structures were found in many of the DES-treated male mice, as was a low but significant number of reproductive tract neoplasms.
متن کاملPrenatal and perinatal correlates of adult mammographic breast density.
BACKGROUND Adult mammographic percent density is one of the strongest known risk factors for breast cancer. In utero exposure to high levels of endogenous estrogens (or other pregnancy hormones) has been hypothesized to increase breast cancer risk in later life. We examined the hypothesis that those factors associated with higher levels of estrogen during pregnancy or shortly after birth are as...
متن کاملInduction of urogenital neoplasia and abnormalities from prenatal exposure to diethylstilbestrol.
The occurrence of vaginal clear cell adenocarcinoma in young women following exposure in utero to diethylstilbestrol (DES) is now well documented. In addition to this carcinogenic potential. DES has been shown to be teratogenic. In females, the DES-related malformations include vaginal adenosis, transverse ridges of the vagina or cervix and uterine abnormalities. Although no neoplasms have been...
متن کاملLong-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol.
The association between treatment of pregnant women with diethylstilbestrol (DES) and reproductive tract abnormalities in their female offspring is well known. Reports of comparable in utero exposure in animals are few. In this paper, pregnant outbred mice were treated s.c. with daily doses of DES ranging from 0.01 to 100 jug/kg on Days 9 to 16 of gestation. This period corresponds with major o...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2018
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.31524